Depression is also associated with a 1.5 to 2 times higher risk of cardiovascular disease, regardless of other known risk factors, and is itself directly or indirectly associated with risk factors such as smoking and obesity. People with severe depression are less likely to follow medical recommendations for the treatment and prevention of cardiovascular disease, which further increases their risk of medical complications.  In addition, cardiologists cannot detect underlying depression that complicates a cardiovascular problem in their custody.  With the growing awareness of the problem of loneliness, community projects, which explicitly aimed to relieve them, became more and more frequent in the second half of the 20th century, with even more beginnings in the 21st century. There have been thousands of such projects in North and South America, Europe, Asia and Africa. Some campaigns are conducted across the country under the control of charity dedicated to helping with loneliness, while others may be local projects, sometimes led by a group for which loneliness assistance is not their main objective. For example, housing companies that want to ensure the lives of multigenerationals, by promoting social interaction between young people and the elderly, or in some cases prescribed by the contract. Projects range from friendship programs, which facilitate only two people who meet, to large group activities that often pursue goals other than helping with loneliness. How to have fun, improve physical health through exercise or participate in conservation efforts.    All possible situations and events can cause loneliness, especially in combination with certain personality characteristics for vulnerable individuals. For example, an extroverted, very social person is more likely to feel alone when they live where they have a low population density and with whom they can interact with fewer people.
Loneliness can sometimes even be caused by events that can normally be expected to be relieved: for example, the birth of a child (if there is significant postpartum depression) or after marriage (especially if the marriage proves unstable, excessively troublesome for previous relationships or emotionally cold). In addition to the effects of external events, loneliness can be aggravated by existing mental illnesses such as chronic depression and anxiety.   The extent of anatomical and physiological factors on severe depression is unknown, but is thought to be significant. In addition to socio-economic factors (for example. B the loss of a job and a sense of deprivation of economic rights), the above factors are considered the main reasons why you would suffer from a severe depressive disorder. There are several reasons why women are more often affected by a severe depression disorder, but it is mainly due to the tendency of depression to experience other mental illnesses and illnesses.